Cambridge Doctors on the Cusp of Revolutionary MS Treatments

Cambridge Doctors on the Cusp of Revolutionary MS Treatments

Doctors in Cambridge are pioneering a new MS treatment combining metformin with clemastine, potentially revolutionizing care for patients.

Exciting Breakthrough in MS Treatment

Doctors at the University of Cambridge are optimistic about a groundbreaking treatment approach for multiple sclerosis (MS) that may soon be available. After trials suggested the potential to repair nerve damage, researchers are combining metformin—a diabetes medication—with clemastine, an antihistamine, aiming to restore myelin, the protective sheath surrounding nerve cells that is compromised in MS.

The Science Behind the Breakthrough

Previous studies on animals indicated that metformin could enhance clemastine's effects on myelin repair. Now, for the first time, these two drugs have been tested together on humans. Dr. Nick Cunniffe, who led the trial, expressed confidence that remyelination could significantly halt the progression of MS-related disabilities. However, he cautioned that further research is needed to assess long-term benefits and possible side effects.

Hope for the Future

Dr. Emma Gray from the MS Society, which funded the trial, highlighted the excitement surrounding these results, suggesting they could revolutionize MS treatment. With over 150,000 individuals living with MS in the UK, traditional therapies have focused on the immune system, leaving a gap in addressing the underlying nerve damage. This research could potentially fill that gap and improve lives.

A Participant's Perspective

One trial participant, Hannah Threlfall, diagnosed with relapsing MS, shared her hope that this research might lead to effective treatments for all MS patients. "Even small ripples have long-lasting effects," she noted, emphasizing the importance of ongoing research.

Next Steps and Presentation

The trial results will be presented at the European Committee for Treatment and Research in Multiple Sclerosis in Barcelona, furthering the dialogue on innovative approaches to MS treatment.

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